阿帕加德
SANGI first encountered hydroxyapatite on acquiring a patent from the US National Space and Aeronautics Authority (NASA) in the 1970s. NASA was seeking ways to replace mineral lost from the teeth and bones of astronauts in a gravity-free environment. It proposed using a precursor substance, brushite, to create new hydroxyapatite, the mineral of the teeth. SANGI took this idea one step further and proposed supplying hydroxyapatite itself, directly in toothpaste, to replenish tooth mineral with everyday use .
Hydroxyapatite was hard to obtain, so SANGI hired its first young scientists and synthesis of this remarkable substance began. Researchers from Japan's Tokyo Medical and Dental University, Hokkaido University and Gifu (now Asahi) University carried out in vitro remineralization and early plaque control testing, and a toothpaste manufacturer (SANGI's manufacturer to this day, Nippon Zettoc Co., Ltd.) succeeded with some difficulty in incorporating it in toothpaste. The manufacturers found SANGI's ingredient behaved quite differently from other calcium phosphates they had previously worked with. The result was the world's first hydroxyapatite-containing toothpaste APADENT, launched in 1980, followed by a second brand, APAGARD, in 1985.
納米技術 - SANGI的專利 <mHAP>成分的研發
阿帕加德 是納米羥基磷灰石牙膏的先驅，具有抗齲齒和牙釉質修復作用。
羥基磷灰石 (HAP)
天然存在的磷酸鈣化合物，我們牙齒和骨骼的主要成分
■安全、可食用、高度生物相容性
■廣泛用於醫療和牙科應用和食品
■主要的身體成分（骨骼的60%，牙釉質的97%）
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